ea0029p202 | Calcium & Vitamin D metabolism | ICEECE2012
Vuolo L.
, Di Somma C.
, Negri A.
, Pivonello C.
, Savanelli M.
, Faggiano A.
, Guerra E.
, Pivonello R.
, Colao A.
Introduction: In addition to its well known effects on calcium homeostasis and bone metabolism, growing evidences shows that vitamin D plays an important role in regulation of cancer angiogenesis, cell apoptosis, differentiation, and proliferation. Vitamin D acts through vitamin D receptor (VDR), an intracellular nuclear receptor. It was found an association between different cancer histotypes and single nucleotide polymorphisms (SNPs) of VDR. Despite the close relationship be...